The effects of sodium lauryl sulphate (SLS), a surfactant widely used as a wetting agent on the in vitro release of ciprofloxacin hydrochloride (CPF) embedded in four different polymers; ethylcellulose (Etcell), hydroxyethylcellulose (HEC), eudragit l-100 (EUD) and hydroxy propylmethyl cellulose (HPMC) were investigated. The wet granulation method of massing and screening using hydro alcoholic medium was used. CPF tablets of all the polymers were of good physical quality with respect to appearance, drug content uniformity, hardness, weight variation and friability. In vitro release studies show that, ethylcellulose extended drug release more than the other polymers, while the fastest release was obtained from eudragit. The presence of sodium lauryl sulphate (SLS) led to about 2 ââ?¬â?? 3 fold increase in the rate of drug dissolution from HPMC matrices while further decreasing dissolution rate in Etcell matrices. The overall result demonstrates that drug release was found to be dependent on both polymer type and concentration of the surfactant. Kinetic studies show that, drug release was both by diffusion and erosion of polymers depending on polymer type, with the presence of SLS only significantly affecting HPMC matrices.
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